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UWA-101 (hydrochloride) is an analytical reference material that is structurally categorized as an amphetamine. It inhibits both serotonin and dopamine reuptake (Kis = 467 and 894 nM, respectively), but has no effect on the reuptake of noradrenaline (Ki > 50,000 nM).1 UWA-101 enhances L-DOPA anti-parkinsonian action without exacerbating dyskinesia.2 This product is intended for research and forensic applications. | [References]
1. Johnston, T.H., Millar, Z., Huot, P., et al. A novel MDMA analogue, UWA-101, that lacks psychoactivity and cytotoxicity, enhances L-DOPA benefit in parkinsonian primates FASEB J. 26(5),2154-2163(2012).
2. Huot, P., Johnston, T.H., Gandy, M.N., et al. The monoamine re-uptake inhibitor UWA-101 improves motor fluctuations in the MPTP-lesioned common marmoset PLoS One 7(9),(2012). |
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