| Identification | Back Directory | [Name]
Shizukaol B | [CAS]
142279-40-1 | [Synonyms]
Shizukaol B
Propanoic acid, 2-[(3R,3aS,3bR,4aS,5aS,6S,6aR,7aS,8S,12E,24aS,24bR,27R)-3,3a,3b,4,4a,5,5a,6,6a,7,7a,8,9,11,14,16,17,18,19,24b-eicosahydro-3,8-dihydroxy-3a,6,12-trimethyl-2,11,16,19,23-pentaoxo-23H-6,8,24a,22-[1]propanyliden[3]ylidyne-21H,24aH-cyclopropa[r]cycloprop[1,2]acenaphtho[4,5-u][1,5,10,15]te... | [Molecular Formula]
C40H44O13 | [MOL File]
142279-40-1.mol | [Molecular Weight]
732.77 |
| Hazard Information | Back Directory | [Uses]
Shizukaol B is a lindenane-type dimeric sesquiterpene, used to be isolated from the whole plant of Chloranthus henryi. Shizukaol B has anti-inflammatory effect against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. Shizukaol B inhibits iNOS and COX-2, and suppresses NO production, TNF-α, and IL-1β expression[1]. | [IC 50]
COX-2; iNOS; IL-1β | [References]
[1] Pan LL, et al. Shizukaol B, an active sesquiterpene from Chloranthus henryi, attenuates LPS-induced inflammatory responses in BV2 microglial cells. Biomed Pharmacother. 2017 Apr;88:878-884. DOI:10.1016/j.biopha.2017.01.152 |
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