| Identification | Back Directory | [Name]
9(E),11(E)-9-nitro Conjugated Linoleic Acid | [CAS]
1417651-32-1 | [Synonyms]
9(E),11(E)-9-nitro Conjugated Linoleic Acid | [Molecular Formula]
C18H31NO4 | [MOL File]
1417651-32-1.mol | [Molecular Weight]
325.44 |
| Hazard Information | Back Directory | [Biological Activity]
9(E),11(E)-9-nitro Conjugated linoleic acid (9E,11E-9-nitro CLA) is a nitrated fatty acid. It is formed from 9Z,11E-CLA upon exposure to acidified nitrite, peroxynitrite, gaseous nitrogen dioxide, or a combination of myeloperoxidase, hydrogen peroxide, and nitrite.1 It is also formed in LPS-stimulated RAW 264.7 macrophages, an effect that can be reduced by the nitric oxide synthase (NOS) inhibitor L-NAME .2 9E,11E-9-nitro CLA has been found in human plasma. | [References]
1.Woodcock, S.R., Salvatore, S.R., Bonacci, G., et al.Biomimetic nitration of conjugated linoleic acid: Formation and characterization of naturally occurring conjugated nitrodienesJ. Org. Chem.79(1)25-33(2014)
2.Bonacci, G., Baker, P.R.S., Salvatore, S.R., et al.Conjugated linoleic acid is a preferential substrate for fatty acid nitrationJ. Biol. Chem.287(53)44071-44082(2012)
|
|
|