| Identification | Back Directory | [Name]
GC376 | [CAS]
1416992-39-6 | [Synonyms]
376
GC376
GPC376
GC376 sodium
3 alpha, 7 alpha-dyhydroxy-6-ethidene- cholanic acid
Sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-4-methylpentanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate | [Molecular Formula]
C21H32N3NaO8S | [MDL Number]
MFCD31382192 | [MOL File]
1416992-39-6.mol | [Molecular Weight]
509.55 |
| Hazard Information | Back Directory | [Description]
GC376 is an inhibitor of the main protease Mpro (3CLpro) in coronaviruses as well as picornaviruses. This broad-spectrum antiviral compound has been used as investigational veterinary drug for treatment of feline infectious peritonitis virus (FIPV) infections. Recent studies also showed that GC376 inhibits the main protease Mpro (3CLpro) from SARS-CoV-2 with IC50 of 0.03 μM and EC50 of 3.37 μM. | [Uses]
GC 376 sodium is a potential small molecule inhibitor which may be able to reduce the viral load of SARS-CoV-2 3CLpro. |
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