| Identification | Back Directory | [Name]
2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E)- | [CAS]
1415662-57-5 | [Synonyms]
WAY-272077
WAY 272077,WAY272077
2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-2-thiazolyl-, (2E)- | [Molecular Formula]
C14H14N2O3S | [MOL File]
1415662-57-5.mol | [Molecular Weight]
290.34 |
| Chemical Properties | Back Directory | [density ]
1.307±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 15 mg/mL (51.66 mM);Ethanol: Insoluble | [form ]
Solid | [pka]
6.74±0.70(Predicted) | [color ]
Off-white to light yellow | [Water Solubility ]
Water: Insoluble |
| Hazard Information | Back Directory | [Uses]
SphK1&2-IN-1 is a SphK inhibitor targeting to SphK1 and SphK2. SphK1&2-IN-1 has thermal stability[1][2]. | [IC 50]
SphK1; SphK2 | [References]
[1] Vogt D, et al. Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5354-67. DOI:10.1016/j.bmc.2014.07.044
[2] Nong W, et al. Synthesis and biological evaluation of a new series of cinnamic acid amide derivatives as potent haemostatic agents containing a 2-aminothiazole substructure. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4506-4511. DOI:10.1016/j.bmcl.2017.07.058 |
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