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ChemicalBook--->CAS DataBase List--->1415637-72-7

1415637-72-7

1415637-72-7 Structure

1415637-72-7 Structure
IdentificationBack Directory
[Name]

PF-05085727
[CAS]

1415637-72-7
[Synonyms]

PF-05085727
PF-05085727 >=98% (HPLC)
4-(AZETIDIN-1-YL)-1-METHYL-3-(1-METHYL-5-(4-(TRIFLUOROMETHYL)PHENYL)-1H-PYRAZOL-4-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE
1H-Pyrazolo[3,4-d]pyrimidine, 4-(1-azetidinyl)-1-methyl-3-[1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl]-
[Molecular Formula]

C20H18F3N7
[MDL Number]

MFCD31556859
[MOL File]

1415637-72-7.mol
[Molecular Weight]

413.4
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 62.5 mg/mL (151.19 mM; Need ultrasonic)
[form ]

Solid
[color ]

White to yellow
Hazard InformationBack Directory
[Biological Activity]

PF-05085727 is a potent inhibitor against cGMP-dependent phosphodiesterase PDE2 (PDE2A; IC50 = 2.3 nM) with >500-fold selectivity over other PDEs. Its 3-[(18)F]fluoroazetidinyl derivative ([(18)F]PF-05270430) has been successfully applied via i.v. injection as a brain-permeant probe for imaging brain PDE2 in live cynomolgus monkeys by positron emission tomography (PET).
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