| Identification | Back Directory | [Name]
PF-05085727 | [CAS]
1415637-72-7 | [Synonyms]
PF-05085727
PF-05085727 >=98% (HPLC)
4-(AZETIDIN-1-YL)-1-METHYL-3-(1-METHYL-5-(4-(TRIFLUOROMETHYL)PHENYL)-1H-PYRAZOL-4-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE
1H-Pyrazolo[3,4-d]pyrimidine, 4-(1-azetidinyl)-1-methyl-3-[1-methyl-5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl]- | [Molecular Formula]
C20H18F3N7 | [MDL Number]
MFCD31556859 | [MOL File]
1415637-72-7.mol | [Molecular Weight]
413.4 |
| Hazard Information | Back Directory | [Biological Activity]
PF-05085727 is a potent inhibitor against cGMP-dependent phosphodiesterase PDE2 (PDE2A; IC50 = 2.3 nM) with >500-fold selectivity over other PDEs. Its 3-[(18)F]fluoroazetidinyl derivative ([(18)F]PF-05270430) has been successfully applied via i.v. injection as a brain-permeant probe for imaging brain PDE2 in live cynomolgus monkeys by positron emission tomography (PET). |
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Energy Chemical
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InvivoChem
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13549236410 |
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https://www.invivochem.cn/ |
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Merck KGaA
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MedChemExpress
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