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ChemicalBook--->CAS DataBase List--->14046-55-0

14046-55-0

14046-55-0 Structure

14046-55-0 Structure
IdentificationBack Directory
[Name]

(3,4-Dimethoxyphenyl)isopropyl ketone
[CAS]

14046-55-0
[Synonyms]

Nsc63844
Verapamil Impurity L
Verapamil EP Impurity L
verapamil impurities879
3',4'-Dimethoxyisobutyrophenone
Isobutyrophenone, 3',4'-dimethoxy-
1-(3,4-Dimethoxyphenyl)-2-methylpro
Verapamil Hydrochloride EP Impurity L
(3,4-Dimethoxyphenyl)isopropyl ketone
3',4'-DIMETHOXY-2-METHYLPROPIOPHENONE
1-(3,4-Dimethoxyphenyl)-2-methyl-1-propanone
1-Propanone, 1-(3,4-dimethoxyphenyl)-2-methyl-
Verapamil Impurity 12(Verapamil EP Impurity L)
[Molecular Formula]

C12H16O3
[MDL Number]

MFCD01718113
[MOL File]

14046-55-0.mol
[Molecular Weight]

208.25
Chemical PropertiesBack Directory
[Boiling point ]

165-170℃ (10 Torr)
[storage temp. ]

Refrigerator, under inert atmosphere
[solubility ]

Chloroform (Sparingly), Methanol (Slightly)
[form ]

Oil
[color ]

Colourless
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H319-H315-H302-H335
[Precautionary statements ]

P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Hazard InformationBack Directory
[Uses]

1-(3,4-Dimethoxyphenyl)-2-methyl-1-propanone (Verapamil EP Impurity L) is a compound being considered as an inhibitor of melanogenesis. It may reduce growth or pigment production in melanocyte cells.
[Preparation]

Preparation by acylation of veratrole,
with isobutyryl chloride in the presence of aluminium chloride (85%)
with isobutyric acid in the presence of PPA at 60° for 2.5 h
with isobutyric anhydride in acetonitrile in the presence of TiCl(OTf)3 /TfOH at r.t. for 12 h (89%).
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