| Identification | Back Directory | [Name]
CHAETOMIN | [CAS]
1403-36-7 | [Synonyms]
CTM
CS-1
HSF4
SSFA2
CHETOMIN
CHAETOMIN
NSC 289491
CHETOMIN(RG)
DKFZp313O1039
Chetomin,Chaetomin
Chetomin
(NSC 289491)
Chetomin,Chaetomiumspecies
ANTI-HSF4 antibody produced in mouse
Monoclonal Anti-HSF4 antibody produced in mouse
Stereoisomer of 2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-[3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione
(3S,5aR,10bS,11aS)-2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-(3-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl)methyl]-1H-indol-1-yl]-2-methyl-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione
3,11a-Epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione, 2,3,5a,6,10b,11-hexahydro-3-(hydroxymethyl)-10b-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-, (3S,5aR,10bS,11aS)- | [Molecular Formula]
C31H30N6O6S4 | [MDL Number]
MFCD28137713 | [MOL File]
1403-36-7.mol | [Molecular Weight]
710.87 |
| Chemical Properties | Back Directory | [Melting point ]
218-220℃ (chloroform ) | [density ]
1.78±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble | [form ]
Off-white to fawn solid. | [pka]
12.69±0.10(Predicted) | [color ]
Off-white to fawn | [biological source]
mouse |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
45 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [Toxicity]
rat,LD50,oral,75mg/kg (75mg/kg),"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 174, 1980. |
| Hazard Information | Back Directory | [Uses]
Chetomin is an antibacterial agent and inhibitor of HIF. | [Definition]
ChEBI: An organic heteropentacyclic compound of the class of epipolythiodioxopiperazine. Isolated from Chaetomium globosum and Farrowia seminuda, it exhibits immunosuppressive activity. | [Biochem/physiol Actions]
Chetomin is a natural metabolite produced by several species of the genus Chaetomium. Chetomin is an epidithiodioxopiperazine known to disrupt the hypoxia-inducible factor (HIF) pathway. Chetomin blocks the interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) binding protein (CBP), thereby attenuating hypoxia-inducible transcription. Disrupting the ability of tumors to adapt to hypoxia leads to decreased tumor growth and can serve as an antitumor stratagy. Chetomin also suppresses the proliferation of LPS-induced mouse spleen lymphocytes. | [in vivo]
Chetomin (0~100 mg/kg; p.o.) inhibits lung tumorigenesis in NSCLC mouse models[1].
Chetomin markedly decreases tumor formation in several murine models of NSCLC[1]. | Animal Model: | Mouse | | Dosage: | 0~100 mg/kg | | Administration: | P.o. | | Result: | Inhibited lung tumorigenesis in NSCLC mouse models.
|
| [IC 50]
HSP90 | [storage]
+4°C |
|
| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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Lynnchem
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86-(0)29-85992781 17792393971 |
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http://www.lynnchem.com/ |
| Company Name: |
Novachemistry
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https://www.novachemistry.com/ |
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BOC Sciences
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https://www.bocsci.com |
| Company Name: |
DC Chemicals
|
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021-58447131 13564518121 |
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http://m.is0513.com/ShowSupplierProductsList927327/0.htm |
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