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ChemicalBook--->CAS DataBase List--->1402836-58-1

1402836-58-1

1402836-58-1 Structure

1402836-58-1 Structure
IdentificationBack Directory
[Name]

NLG919
[CAS]

1402836-58-1
[Synonyms]

CS-820
NLG919
GDC0919
GDC-0919
GDC 0919
NLG919, >=98%
NLG919;NLG-919
IDO inhibitor 7
NLG-919 analogue
NLG919;NAVOXIMOD
NLG919 USP/EP/BP
NLG919 (GDC-0919)
NLG919(GDC-0919,Navoximod)
5H-Imidazo[5,1-a]isoindole-5-ethanol, α-cyclohexyl-
alpha-Cyclohexyl-5H-imidazo[5,1-a]isoindole-5-ethanol
1-CYCLOHEXYL-2-(5H-IMIDAZO[5,1-A]ISOINDOL-5-YL)ETHANOL
NLG-919; NLG 919; IDO INHIBITOR;GDC-0919;GDC 0919;GDC0919
1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethan-1-ol
5-(2-Cyclohexyl-2-hydroxyethyl)-5H-imidazo[5,1-a]isoindole
1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol NLG919
NLG919 1-CYCLOHEXYL-2-(5H-IMIDAZO[5,1-A]ISOINDOL-5-YL)ETHANOL
[EINECS(EC#)]

1592732-453-0
[Molecular Formula]

C18H22N2O
[MDL Number]

MFCD26142661
[MOL File]

1402836-58-1.mol
[Molecular Weight]

282.38
Chemical PropertiesBack Directory
[Melting point ]

143 - 146°C
[Boiling point ]

524.6±33.0 °C(Predicted)
[density ]

1.27±0.1 g/cm3(Predicted)
[storage temp. ]

-20°C
[solubility ]

Soluble in DMSO (up to 15 mg/ml)
[form ]

solid
[pka]

14.85±0.20(Predicted)
[color ]

White
[Stability:]

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard InformationBack Directory
[Description]

(±)-NLG-919 is an indoleamine 2,3-dioxygenase (IDO) pathway inhibitor (Ki = 7 nM; EC50 = 75 nM). (±)-NLG-919 inhibits IDO-induced T cell suppression and restores T cell response during allogenic mixed lymphocyte reactions in vitro (ED50s = 80 and 120 nM, respectively). In vivo, (±)-NLG-919 induces a 95% reduction in tumor volume when administered in conjunction with a pmel-1 T cell vaccine. Formulations containing (±)-NLG-919 are under investigation in clinical trials for treatment of glioblastoma, melanoma, pancreatic, and breast cancers.
[Uses]

NLG919 is a potent indoleamine-2,3-dioxygenase (IDO) pathway inhibitor and is suitable for the treatment of immunosuppression associated with cancer.
[target]

IDO pathway
[storage]

Store at -20°C
[References]

1) Mautino?et al.?(2013),?NLG919, a novel indolamine-2,3-dioxygenase (IDO)-pathway inhibitor drug candidate for cancer therapy;?Cancer Res.?73?issue 8 supplement?491 2) Li?et al.?(2014),?The indolamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma;?J. Immunother. Cancer?2?21 3) Meng?et al.?(2017),?Combinatorial antitumor effects of indoleamine 2,3-dioxygenase inhibitor NLG919 and paclitaxel in a murine B16-F10 melanoma model;?Int. J. Immunopathol. Pharmacol.?30?215
Spectrum DetailBack Directory
[Spectrum Detail]

NLG919(1402836-58-1)1HNMR
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