| Identification | Back Directory | [Name]
GV-58 | [CAS]
1402821-41-3 | [Synonyms]
GV-58
GV-58 >=97% (HPLC)
(2R)-2-[[6-[[(5-Methylthiophen-2-yl)methyl]amino]-9-propyl-9H-purin-2-yl]amino]butan-1-ol
1-Butanol, 2-[[6-[[(5-methyl-2-thienyl)methyl]amino]-9-propyl-9H-purin-2-yl]amino]-, (2R)- | [Molecular Formula]
C18H26N6OS | [MDL Number]
MFCD28385865 | [MOL File]
1402821-41-3.mol | [Molecular Weight]
374.5 |
| Chemical Properties | Back Directory | [Boiling point ]
599.6±60.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (133.51 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
solid | [pka]
14.56±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
GV-58 is a roscovitine analog th at retains the ability to prolong the open state of calcium channelsbut unlike roscovitineis inactive against Cdk activity. GV-58 is a selective agonist of N-type and P/Q type calcium channelswhich are critical to the triggering of neurotransmitter release at the neuromuscular junction. GV-58 has been studied as a possible therapeutic agent in a mouse model of Lambert-Eaton myasthenic syndrome (LEMS). The EC50 values for activation of N-P/Q- and L- type calcium channels are 6.89.9 and >100 μMrespectively. | [storage]
+4°C |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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