| Identification | Back Directory | [Name]
ATPA | [CAS]
140158-50-5 | [Synonyms]
ATPA
(R,S)-ATPA
ATP synthase α chain
alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionate
(RS)-A-AMINO-3-HYDROXY-5-TERT-BUTYL-4-ISOXAZOLEPROPIONIC ACID
(R,S)-ALPHA-AMINO-3-HYDROXY-5-T-BUTYL-4-ISOXAZOLEPROPIONIC ACID
(RS)-ALPHA-AMINO-3-HYDROXY-5-TERT-BUTYL-4-ISOXAZOLEPROPIONIC ACID
(RS)-2-AMINO-3-(3-HYDROXY-5-TERT-BUTYLISOXAZOL-4-YL)PROPANOIC ACID
4-Isoxazolepropanoic acid, α-amino-5-(1,1-dimethylethyl)-2,3-dihydro-3-oxo- | [Molecular Formula]
C10H16N2O4 | [MDL Number]
MFCD01860864 | [MOL File]
140158-50-5.mol | [Molecular Weight]
228.24 |
| Chemical Properties | Back Directory | [density ]
1.263±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at +4°C | [solubility ]
DMSO: 10 mg/mL
| [form ]
solid
| [pka]
2.15±0.10(Predicted) | [color ]
white
|
| Hazard Information | Back Directory | [Uses]
(R,S)-ATPA is a selective and potent GluR5 kainate receptor agonist (1,2). It inhibits GluK2 kainate receptor-JNK3 protein pathway by activating GABA type A receptor in rat after cerebral ischemia-reperfusion injury (3). (R,S)-ATPA is a neuroprotective agent. | [Definition]
ChEBI: 2-amino-3-(5-tert-butyl-3-oxo-4-isoxazolyl)propanoic acid is an alpha-amino acid. | [Biological Activity]
A selective and potent GluR5 kainate receptor agonist (K i = 4.3 nM), inactive at GluR6 (K i > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (K i values of 6 - 14 μ M). Also available as part of the Kainate Receptor Tocriset™ . | [storage]
Store at -20°C |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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