| Identification | Back Directory | [Name]
CGP 52432 | [CAS]
139667-74-6 | [Synonyms]
P52432
CGP 52432
CGP52432 >=98% (HPLC)
CGP 52432;CGP-52432;CGP 52432
(3-((3,4-dichlorobenzyl)amino)propyl)(diethoxymethyl)phosphinic acid
3-([[[(3,4-DICHLOROPHENYL)METHYL]AMINO]PROPYL] DIETHOXYMETHYL)PHOSPHINIC ACID
Phosphinic acid, P-[3-[[(3,4-dichlorophenyl)methyl]amino]propyl]-P-(diethoxymethyl)- | [EINECS(EC#)]
-0 | [Molecular Formula]
C15H24Cl2NO4P | [MDL Number]
MFCD02262128 | [MOL File]
139667-74-6.mol | [Molecular Weight]
384.24 |
| Chemical Properties | Back Directory | [Boiling point ]
544.4±50.0 °C(Predicted) | [density ]
1.258±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble1mg/mL, clear (warmed) | [form ]
powder | [pka]
2.26±0.50(Predicted) | [color ]
white to beige | [Water Solubility ]
Soluble in water (10mM, gentle warming) |
| Hazard Information | Back Directory | [Uses]
CGP52432 has been used as a γ-aminobutyric acid B (GABAB) antagonist:
- to study its effects on the simulation of the onset of status epilepticus (SE) in mice
- for voltage-clamp recording in mice neurons
- to study its effects on the GABAB receptor-mediated neurotransmission in guinea pig hippocampus
| [Definition]
ChEBI: 3-[(3,4-dichlorophenyl)methylamino]propyl-(diethoxymethyl)phosphinic acid is a dichlorobenzene. | [Biological Activity]
Potent, selective GABA B receptor antagonist (IC 50 = 85 nM). | [Biochem/physiol Actions]
CGP52432 participates in inhibiting the glycine overflow in the hippocampus. | [storage]
+4°C (desiccate) |
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