| Identification | Back Directory | [Name]
1-((1-(2-aminopyrimidin-4-yl)-2-((2-methoxyethyl)amino)-1H-benzo[d]imidazol-6-yl)ethynyl)cyclohexanol | [CAS]
1394121-05-1 | [Synonyms]
181525
GNE-2861
1394121-05-1
GNE-2861; GNE 2861; GNE2861.
1-[2-[3-(2-aminopyrimidin-4-yl)-2-(2-methoxyethylamino)benzimidazol-5-yl]ethynyl]cyclohexan-1-ol
1-[2-[1-(2-Amino-4-pyrimidinyl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl]ethynyl]cyclohexanol
1-((1-(2-aminopyrimidin-4-yl)-2-((2-methoxyethyl)amino)-1H-benzo[d]imidazol-6-yl)ethynyl)cyclohexanol
Cyclohexanol, 1-[2-[1-(2-amino-4-pyrimidinyl)-2-[(2-methoxyethyl)amino]-1H-benzimidazol-6-yl]ethynyl]- | [Molecular Formula]
C22H26N6O2 | [MOL File]
1394121-05-1.mol | [Molecular Weight]
406.48 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:82.83(Max Conc. mg/mL);203.77(Max Conc. mM)
Ethanol:40.65(Max Conc. mg/mL);100.0(Max Conc. mM) | [form ]
A solid | [color ]
White to yellow |
| Hazard Information | Back Directory | [Biological Activity]
GNE 2861 is a PAK inhibitor with selectivity for group II. It inhibits PAK4, PAK5 and PAK6 with IC50 values of 7.5, 36 and 126 nM, respectively. | [in vitro]
GNE-2861 is compound 4 from the reference. | [target]
IC50: 7.5 nM (PAK4), 36 nM (PAK5), 126 nM (PAK6) | [storage]
Store at -20°C |
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