| Identification | Back Directory | [Name]
GALANTIDE | [CAS]
138579-66-5 | [Synonyms]
M15
GALANTIDE
M 15 (peptide)
Galantide, M15
GalantideGalanti
GALANTIDE| Galantide
Galantide, ≥90% (HPLC)
GWTLNSAGYLLGPQQFFGLM-NH2
Galanin(1-13)-substance P(5-11)
Rabbit Anti-PKA R2/PKA IIÎ
GALANIN (1-13)-SUBSTANCE P (5-11) AMIDE
gly-trp-thr-leu-asn-ser-ala-gly-tyr-*leu-leu-gly-
Galanin (1-13)-Substance P (5-11), amide, Galantide
GLY-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-*LEU -LEU-GLY-PR
Galanin (1-13)-Substance P (5-11) aMide
Galantide, M15
GLY-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-GLY-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
GLY-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-GLY-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET AMIDE
H-GLY-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-GLY-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
Gly-L-Trp-L-Thr-L-Leu-L-Asn-L-Ser-L-Ala-Gly-L-Tyr-L-Leu-L-Leu-Gly-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2
L-Methioninamide, glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl- | [Molecular Formula]
C104H151N25O26S | [MDL Number]
MFCD00144384 | [MOL File]
138579-66-5.mol | [Molecular Weight]
2199.53 |
| Chemical Properties | Back Directory | [Boiling point ]
2345.4±65.0 °C(Predicted) | [density ]
1.305±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
9.82±0.15(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Galantide, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide recognizes two classes of galanin binding sites (KD<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide dose dependently (IC50=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. Galantide appears to bind to a single population of SP receptors (KD~40 nM)[1][2][3]. | [in vivo]
Intracerebroventricular injection of galanin (5 micrograms/rat) inhibited sexual behavior in experienced male rats--without producing any other locomotor or behavioral deficit-, injection of the galanin antagonist, galantide, by the same route (1 or 2 micrograms/rat) stimulated sexual behavior (improving arousal, motivation and performance indexes) and antagonized the effect of galanin[2]. Galantide ameliorates mild acute pancreatitis (AP). Galantide significantly reduces AP-induced hyperenzymemia by 41–49%[3]. Galantide has been found to improve social memory in 'socialrecognition' test when i.c.v. administered at doses varying from 6-6000 nM[4]. | [storage]
Store at -20°C | [References]
[1] Langel U, et al. Design of chimeric peptide ligands to galanin receptors and substance P receptors. Int J Pept Protein Res. 1992;39(6):516-522. DOI:10.1111/j.1399-3011.1992.tb00282.x
[2] Lindskog S, et al. The novel high-affinity antagonist, galantide, blocks the galanin-mediated inhibition of glucose-induced insulin secretion. Eur J Pharmacol. 1992;210(2):183-188. DOI:10.1016/0014-2999(92)90669-u
[3] Mulvaney JM, et al. Galantide distinguishes putative subtypes of galanin receptors in mudpuppy parasympathetic neurons. Eur J Pharmacol. 1995;287(1):97-100. DOI:10.1016/0014-2999(95)00623-6 |
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