| Identification | Back Directory | [Name]
FK 888 | [CAS]
138449-07-7 | [Synonyms]
FK 888
FK888 hydrate
N(2)-(4-Hydroxy-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl)-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide
(4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide
L-Alaninamide, (4R)-4-hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-
L-Alaninamide, trans-4-hydroxy-1-((1-methyl-1H-indol-3-yl)carbonyl)-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-
N2-[(4R)-4-hydroxyl-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl]-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide hydrate
(4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide hydrate | [Molecular Formula]
C36H36N4O4 | [MDL Number]
MFCD00274042 | [MOL File]
138449-07-7.mol | [Molecular Weight]
588.7 |
| Chemical Properties | Back Directory | [Boiling point ]
901.9±65.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥13mg/mL | [form ]
powder | [pka]
13.01±0.40(Predicted) | [color ]
white to tan | [optical activity]
[α]/D -135 to -145°, c = 1 in methanol |
| Hazard Information | Back Directory | [Uses]
FK 888 is a neurokinin NK1 receptor antagonist, which is active both in vivo and in vitro. | [Definition]
ChEBI: (2S,4R)-4-hydroxy-1-[(1-methyl-3-indolyl)-oxomethyl]-N-[(2S)-1-[methyl-(phenylmethyl)amino]-3-(2-naphthalenyl)-1-oxopropan-2-yl]-2-pyrrolidinecarboxamide is a peptide. | [Biological Activity]
Selective, high affinity tachykinin NK 1 receptor antagonist (K i = 0.69 nM) that displays 320-fold selectivity for human over rat NK 1 receptors. Inhibits substance P-induced contraction of isolated guinea pig trachea (IC 50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration. | [storage]
Store at -20°C |
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