| Identification | Back Directory | [Name]
BIM187 | [CAS]
137734-88-4 | [Synonyms]
BIM187
1-Phe-8-Leu-9-Leu-litorin-NH2
L-Leucinamide, D-phenylalanyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl- (9CI) | [Molecular Formula]
C53H76N14O10 | [MDL Number]
MFCD09753288 | [MOL File]
137734-88-4.mol | [Molecular Weight]
1069.26 |
| Hazard Information | Back Directory | [Biological Activity]
bombesin has common effects on the gastrointestinal tract and feeding behavior. bombesin acts on two types of receptors including one with high affinity for neuromedin b and another with high affinity for bombesin and gastrin-releasing peptide (grp). bim 187is a new peptide of bombesin while bim 189 is a potent bombesin antagonis. | [in vitro]
bombesin stimulates mainly the bombesin high-affinity receptor, and bim 187 ([d-phe i ,leu 8'9 ]litorin-nhe), a new bombesin agonist, stimulates the bombesin/grp receptor type. [2]. | [in vivo]
to study the mechanism by which bombesin induces satiety, we studied the effect of bim187 on food intake in rats fed 6 h a day. bim 187 at 4 μg/kg, reduced food intake at 30 min significantly, but did not change the total 6-h food intake. bim 189 (10 mg/kg), had no effect on food intake, even at high doses (20 mg/kg). bim 189 selectively reduced bombesin-induced satiety but had no effect on satiety induced by bim 187 [2]. | [storage]
Store at -20°C | [References]
[1] coy d, wang lh, jiang ny, jensen r. short chain bombesin pseudopeptides with potent bombesin receptor antagonist activity in rat and guinea pig pancreatic acinar cells. eur j pharmacol. 1990 nov 6;190(1-2):31-8.
[2] laferrère b, leroy f, bonhomme g, le gall a, basdevant a, guy-grand b. effects of bombesin, of a new bombesin agonist (bim187) and a new antagonist (bim189) on food intake in rats, in relation to cholecystokinin. eur j pharmacol. 1992 apr 29;215(1):23-8. |
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