| Identification | Back Directory | [Name]
BMS-955829 | [CAS]
1375751-08-8 | [Synonyms]
BMS-955829
(4R,5R)-5-(2,5-DIFLUOROPHENYL)-4-(5-(PHENYLETHYNYL)PYRIDIN-3-YL)OXAZOLIDIN-2-ONE | [Molecular Formula]
C22H14F2N2O2 | [MDL Number]
MFCD30471079 | [MOL File]
1375751-08-8.mol | [Molecular Weight]
376.36 |
| Hazard Information | Back Directory | [Description]
BMS-955829 is a Positive allosteric modulators (PAMs). BMS-955829 shows high functional PAM potency, excellent mGluR5 binding affinity, low glutamate fold shift, and high selectivity for the mGluR5 subtype. BMS-955829 is a potent mGluR5 PAM (EC50 = 2.6 ± 1.0 nM; n = 6), devoid of inherent mGluR5 agonist activity (EC50 > 30μM). The measured binding Ki of BMS-955829 was found to be 1.6 nM, which was in good agreement with its functional potency. |
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| Company Name: |
AstaTech, Inc
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| Tel: |
(215) 785 3197 |
| Website: |
www.astatechinc.com |
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