| Identification | Back Directory | [Name]
ketomethylenebestatin | [CAS]
137028-97-8 | [Synonyms]
ketomethylenebestatin
(2R,5S,6R)-6-amino-5-hydroxy-2-(2-methylpropyl)-4-oxo-7-phenylheptanoic acid | [Molecular Formula]
C17H25NO4 | [MOL File]
137028-97-8.mol | [Molecular Weight]
307.39 |
| Hazard Information | Back Directory | [Description]
Ketomethylenebestatin is a carba-analogue of the aminopeptidase (AP) inhibitor bestatin. This synthesis was carried out by a malonic ester alkylation with the suitably protected halomethyl ketone of (2S,3R)-AHPBA*), followed by a second alkylation with isobutyl bromide of the resulting 4-ketodiester, and subsequent decarboxylation and deprotection. Ketomethylenebestatin is 10 fold less effective as inhibitor of aminopeptidases than bestatin. |
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