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ChemicalBook--->CAS DataBase List--->1361030-48-9

1361030-48-9

1361030-48-9 Structure

1361030-48-9 Structure
IdentificationBack Directory
[Name]

LDC1267
[CAS]

1361030-48-9
[Synonyms]

LDC1267
CS-1641
LDC 1267;LDC-1267
LDC1267 USP/EP/BP
N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-4-ethoxy-1-(4-fluoro-2-methyl-phenyl)pyrazole-3-carboxamide
N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide
1H-Pyrazole-3-carboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluoro-2-methylphenyl)-
[Molecular Formula]

C30H26F2N4O5
[MDL Number]

MFCD28385861
[MOL File]

1361030-48-9.mol
[Molecular Weight]

560.55
Chemical PropertiesBack Directory
[Boiling point ]

628.4±55.0 °C(Predicted)
[density ]

1.32±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

insoluble in H2O; insoluble in EtOH; ≥20.75 mg/mL in DMSO
[form ]

solid
[pka]

9.36±0.70(Predicted)
[color ]

White to off-white
Spectrum DetailBack Directory
[Spectrum Detail]

LDC1267(1361030-48-9)1HNMR
Hazard InformationBack Directory
[Biological Activity]

LDC1267 is a highly selective TAM kinase inhibitor with IC50s of <5 nM, 8 nM, and 29 nM for Mer, Tyro3, and Axl, respectively. Low activity against Met, Aurora B, Lck, Src, and CDK8.
[in vitro]

LDC1267 moderately affected proliferation in 11 of 95 different cell lines with IC50 >5 μM. In NKG2D-activated NK cells, it abrogates the inhibitory effect of Gas6 stimulation.

[in vivo]

In B16F10 melanoma-bearing mice, LDC1267 (20 mg/kg, ip) potently enhanced anti-metastatic NK cell activity and resisted tumor metabolism without severe cytotoxicity.
[target]

TargetValue
Mer
(Cell-free assay)
<5 nM
Tyro3
(Cell-free assay)
8 nM
Axl
(Cell-free assay)
29 nM
[storage]

Store at -20°C
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