| Identification | Back Directory | [Name]
(3AR,7AR)-OCTAHYDRO-2-[1-IMINO-2-(2-METHOXYPHENYL)ETHYL]-7,7-DIPHENYL-4H-ISOINDOL-4-ONE | [CAS]
135911-02-3 | [Synonyms]
RP 67580
Rp 68651
7,7-Diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one
(3aR,7aR)-Octahydro-2-(1-imino-2-(2-methoxyphenyl)ethyl)-7,7-diphenyl-4H-isoindol
(3AR,7AR)-OCTAHYDRO-2-[1-IMINO-2-(2-METHOXYPHENYL)ETHYL]-7,7-DIPHENYL-4H-ISOINDOL-4-ONE
(3aR,7aR)-2-(1-Imino-2-(2-methoxyphenyl)ethyl)-7,7-diphenylhexahydro-1H-isoindol-4(2H)-one
4H-Isoindol-4-one, octahydro-2-(1-imino-2-(2-methoxyphenyl)ethyl)-7,7-diphenyl-, (3ar,7ar)-
4H-Isoindol-4-one, octahydro-2-(1-imino-2-(2-methoxyphenyl)ethyl)-7,7-diphenyl-, (3ar-cis)- | [Molecular Formula]
C29H30N2O2 | [MDL Number]
MFCD00903364 | [MOL File]
135911-02-3.mol | [Molecular Weight]
438.56 |
| Hazard Information | Back Directory | [Uses]
RP 67580 is a neurokinin-1 receptor (NK1) antagonist. | [Biological Activity]
Potent and selective tachykinin NK 1 receptor antagonist (K i values are 2.9 nM and > 10 μ M for rat NK 1 , and rat NK 2 and NK 3 receptors respectively). Displays higher affinity at rat and mouse than human receptors. Antinociceptive in vivo , possibly partly via inhibition of calcium channels. | [in vivo]
RP 67580 (0.03-1 mg/kg; i.v.; single dose) significantly inhibits neurogenic inflammation. | Animal Model: | Male albino Sprague-Dawley rats | | Dosage: | 0.03, 0.1, 0.3, 1 mg/kg | | Administration: | i.v.; single dose | | Result: | Potently and dose-dependently inhibited the strong plasma extravasation caused by electrical stimulation of the saphenous nerve for 15 minutes with an ED50 value of 0.15 mg/kg. |
| [storage]
Store at -20°C |
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