| Identification | Back Directory | [Name]
AC710 | [CAS]
1351522-04-7 | [Synonyms]
AC710
CS-2269
AC 710; AC-710
AC710; AC 710; AC-710
N-(4-(3-(5-tert-butylisoxazol-3-yl)ureido)phenyl)-5-(1-ethyl-2,2,6,6-tetramethylpiperidin-4-yloxy)picolinamide
5-[(1-Ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-N-[4-({[5-(2-methyl-2-propanyl)-1,2-oxazol-3-yl]carbamoyl}amino)phenyl]-2-pyridinecarboxamide
N-[4-[[[[5-(1,1-Dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide
2-Pyridinecarboxamide, N-[4-[[[[5-(1,1-dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-
N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide | [Molecular Formula]
C31H42N6O4 | [MDL Number]
MFCD25976599 | [MOL File]
1351522-04-7.mol | [Molecular Weight]
562.7 |
| Chemical Properties | Back Directory | [Boiling point ]
580.4±50.0 °C(Predicted) | [density ]
1.180±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:13.0(Max Conc. mg/mL);23.1(Max Conc. mM) | [form ]
A crystalline solid | [pka]
10.91±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AC 710 is a globally selective inhibitor of platelet-derived growth factor receptor-family kinases and has been shown to have potential anti-arthritic theapeutic use. | [in vivo]
At 0.3 mg/kg of AC710, tumor growth is temporally inhibited, and growth resumes quickly thereafter. At 3 and 30 mg/kg of AC710, tumors regress completely, and the tumor volume stays suppressed for an extended period after dosing is halted. No body weight loss is observed in animals treated with AC710 at all doses, indicating that it is well tolerated in mice at efficacious doses. AC710 exhibits a significant impact on disease in a dose-dependent fashion in a mouse collagen-induced arthritis (CIA) model, at a dose as low as 3 mg/ kg for 15 days (day 0-14). At 10 and 30 mg/kg, AC710 demonstrates equivalent or slightly better efficacy in reducing the joint swelling and inflammation than dexomethasone administered at a safe dose. AC710 is well tolerated at the tested doses[1]. | [IC 50]
PDGFRα: 1.3 nM (Kd); PDGFRβ: 1 nM (Kd); c-Kit: 1 nM (Kd); FLT3: 0.6 nM (Kd); CSF1R: 1.57 nM (Kd) | [storage]
Store at +4°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
|