| Identification | Back Directory | [Name]
ML 154 | [CAS]
1345964-89-7 | [Synonyms]
ML 154
NCGC 84 (ML154)
3-(Diphenylphosphinothioyl)-2-methyl-1-[(2E)-3-phenyl-2-propen-1-yl]imidazo[1,2-a]pyridinium bromide | [Molecular Formula]
C29H26BrN2PS | [MDL Number]
MFCD28133402 | [MOL File]
1345964-89-7.mol | [Molecular Weight]
545.48 |
| Hazard Information | Back Directory | [Uses]
ML 154 is a potent neuropeptide S receptor antagonist which may be used in the treatment of sleep, anxiety and addiction disorders. | [in vivo]
ML154 (NCGC84; 1 mg/kg; i.p; once) blocks alcohol-induced ERK-phosphorylation in the rat central amygdala, a region involved in regulation of alcohol intake. ML154 also decreases operant alcohol self-administration, and lowers motivation for alcohol reward as measured using progressive ratio responding[1]. | Animal Model: | Male Wistar rats (300-350 g) injected with alcohol[1] | | Dosage: | 1 mg/kg (10% Solutol, 10% N,N-dimethylacetamide, and 80% 10 mM PBS, pH 7.4) | | Administration: | Intraperitoneal injection; once | | Result: | Inhibited alcohol-induced central ERK phosphorylation in vivo. |
| [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|