| Identification | Back Directory | [Name]
6-amino-4-methoxy analogue of ZSTK474 (Compound 10w) | [CAS]
1336890-05-1 | [Synonyms]
6-amino-4-methoxy analogue of ZSTK474 (Compound 10w)
1H-Benzimidazol-6-amine, 2-(difluoromethyl)-1-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)-4-methoxy- | [Molecular Formula]
C20H24F2N8O3 | [MOL File]
1336890-05-1.mol | [Molecular Weight]
462.45 |
| Hazard Information | Back Directory | [Uses]
PI3K-IN-54 (compound 10w) is a pan-PI3K inhibitor. The IC50 values of PI3K-IN-54 for p110α, p110β, and p110δ are 0.22 nM, 1.4 nM, and 0.38 nM, respectively. PI3K-IN-54 can be used in cancer research[1]. | [Biological Activity]
Compound 10w, a substituted pyrazolo [1,5-a] pyrimidine amide derivative, shows good anticancer activity against HeLa cell line, with IC50 of less than 10 μM against HeLa cell. | [IC 50]
p110α: 0.22 nM (IC50); p110β: 1.4 nM (IC50); p110δ: 0.38 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Kumar AKA, et al. Medicinal Chemistry Research. 2017; 26, 714-744. |
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