| Identification | Back Directory | [Name]
(2R,3R)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride | [CAS]
1333998-21-2 | [Synonyms]
2S3R-S Aprepitant
Aprepitant Impurity 4 HCl
Aprepitant Impurity SM3FDY3-1
Aprepitant Impurity SM3FDY3-1 HCl
Des-1,2,4-triazol-3-one-5-methyl (2R,3R,2-(S))-Aprepitant Hydrochloride
(2R,3R)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride | [Molecular Formula]
C20H19ClF7NO2 | [MOL File]
1333998-21-2.mol | [Molecular Weight]
473.812 |
| Hazard Information | Back Directory | [Uses]
Des-1,2,4-triazol-3-one-5-methyl (2R,3R,2-(S))-Aprepitant Hydrochloride is an impurity of Aprepitant (A729800); a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic. |
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