| Identification | Back Directory | [Name]
STEM CELL FACTOR, HUMAN | [CAS]
133352-98-4 | [Synonyms]
RHSCF
HUMAN SF
HUMAN SCF
HUMAN MGF
SCF, HUMAN
REC SCF (HUMAN)
C-KIT LIGAND HUMAN
HUMAN C-KIT LIGAND
HUMAN STEEL FACTOR
RECOMBINANT HUMAN SCF
HUMAN STEM CELL FACTOR
HUMAN SCF/C-KIT LIGAND
STEM CELL FACTOR, HUMAN
REC STEM CELL FACTOR (HUMAN)
MAST CELL GROWTH FACTOR HUMAN
HUMAN MAST CELL GROWTH FACTOR
HUMAN STEM CELL FACTOR/C-KIT LIGAND
STEM CELL FACTOR, HUMAN, RECOMBINANT
c-Kit Ligand, Mast Cell Growth Factor (MGF)
STEM CELL FACTOR, HUMAN, RECOMBINANT, E COLI | [MDL Number]
MFCD00165757 |
| Hazard Information | Back Directory | [General Description]
The KITLG (KIT ligand) gene is mapped to human chromosome 12q21.32. | [Biochem/physiol Actions]
Stem Cell Factor (SCF), also known as c-Kit ligand (KL), steel factor (SLF) and mast cell growth factor (MGF), is a 30 kDa glycoprotein with broad activities on various tissues, including hematopoietic cells, pigment cells, and primordial germ cells. SCF is secreted by endothelial cells, fibroblasts, and bone marrow stromal cells as a membrane-bound form which may be cleaved to release the soluble form. Both forms are active in promoting colony formation from murine bone marrow cells, but membrane-bound SCF is more effective in promoting hematopoieses in vivo, suggesting a role in cellular interactions between hematopoietic and stromal cells. The soluble is thought to exist in solution as a noncovalently linked dimer. SCF is structurally related to M-CSF (CSF-1) and Flt-3/Flk-2 Ligand (FL) with all three sharing a similar size, existence of transmembrane and soluble forms, four conserved cysteines, and alternative splicing exon locations, but they share little sequence homology. SCF alone is a modest colony stimulating factor. However, in the presence of other cytokines such as EPO, TPO, GM-CSF, G-CSF, M-CSF, IL-3, and IL-7, SCF is a potent costimulant that works synergistically to increase the size of myeloid, erythroid or lymphoid lineage colonies without influencing the lineage differentiation of the progenitors. |
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