| Identification | Back Directory | [Name]
4-Piperidinecarboxylic acid, 1-[5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-thiazolyl]- | [CAS]
1331745-61-9 | [Synonyms]
ML372
4-Piperidinecarboxylic acid, 1-[5-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-thiazolyl]- | [Molecular Formula]
C18H20N2O4S | [MOL File]
1331745-61-9.mol | [Molecular Weight]
360.43 |
| Chemical Properties | Back Directory | [Boiling point ]
585.3±60.0 °C(Predicted) | [density ]
1.341±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
4.23±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
ML372 inhibits survival motor neuron (SMN) protein ubiquitination, increases SMN protein stability without affecting mRNA expression. ML372 improves spinal muscular atrophy (SMA) in mice. ML372 is brain penetrant and has a reasonable exposure and half-life in vivo[1]. | [References]
[1]. Mahlet B Abera, et al. ML372 blocks SMN ubiquitination and improves spinal muscular atrophy pathology in mice. JCI Insight. 2016 Nov 17;1(19):e88427. |
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DC Chemicals
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