| Identification | Back Directory | [Name]
10-Vinyl-19-norpregn-4-ene-3,20-dione | [CAS]
13258-85-0 | [Synonyms]
Org OD 02-0
10-Vinyl-19-norprogesterone
10-Vinyl-19-norpregn-4-ene-3,20-dione
19-Norpregn-4-ene-3,20-dione, 10-ethenyl- | [Molecular Formula]
C22H30O2 | [MOL File]
13258-85-0.mol | [Molecular Weight]
326.47 |
| Hazard Information | Back Directory | [Uses]
Org OD 02-0 (10-Ethenyl-19-norprogesterone) is a membrane progesterone receptor α (mPRα)-specific agonist (IC50: 33.9 nM). Org OD 02-0 activates MAPK activity. Org OD 02-0 inhibits prolactin (PRL) secretion in the pituitary[1][2]. | [References]
[1] Kelder J, et al. Comparison between steroid binding to membrane progesterone receptor alpha (mPRalpha) and to nuclear progesterone receptor: correlation with physicochemical properties assessed by comparative molecular field analysis and identification of mPRalpha-specific agonists. Steroids. 2010 Apr;75(4-5):314-22. DOI:10.1016/j.steroids.2010.01.010
[2] Camilletti MA, et al. Participation of membrane progesterone receptor α in the inhibitory effect of progesterone on prolactin secretion. J Neuroendocrinol. 2018 Sep;30(9):e12614. DOI:10.1111/jne.12614 |
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