| Identification | Back Directory | [Name]
Tricyclo[3.3.1.13,7]decane-1-butanamide, N-[2-[2-[(6-chlorohexyl)oxy]ethoxy]ethyl]-α-methyl-, (αR)- | [CAS]
1323151-45-6 | [Synonyms]
HyT36
Tricyclo[3.3.1.13,7]decane-1-butanamide, N-[2-[2-[(6-chlorohexyl)oxy]ethoxy]ethyl]-α-methyl-, (αR)- | [Molecular Formula]
C25H44ClNO3 | [MOL File]
1323151-45-6.mol | [Molecular Weight]
442.08 |
| Chemical Properties | Back Directory | [Boiling point ]
578.2±40.0 °C(Predicted) | [density ]
1.060±0.06 g/cm3(Predicted) | [form ]
Oil | [pka]
15.45±0.46(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Uses]
HyT36 is a low molecular weight hydrophobic tag that promotes the degradation of fusion protein and pseudokinase Her3[1][2][3]. | [References]
[1] Tae HS, et al. Identification of hydrophobic tags for the degradation of stabilized proteins. Chembiochem. 2012 Mar 5;13(4):538-41. DOI:10.1002/cbic.201100793
[2] Rubner S, et al. Poloxin-2HT+: changing the hydrophobic tag of Poloxin-2HT increases Plk1 degradation and apoptosis induction in tumor cells. Org Biomol Chem. 2019 Mar 20;17(12):3113-3117. DOI:10.1039/c9ob00080a
[3] Neklesa TK, et al. A bidirectional system for the dynamic small molecule control of intracellular fusion proteins. ACS Chem Biol. 2013 Oct 18;8(10):2293-2300. DOI:10.1021/cb400569k |
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