| Identification | Back Directory | [Name]
N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE | [CAS]
132172-61-3 | [Synonyms]
DOTAP
DOTMA
Lipofectin
dotap chloride
DOTAP CHLORIDE SALT
N-[2,3-Di(oleoyloxy)propyl]-N,N,N-trimethylaminium
2,3-Bis(oleoyloxy)-N,N,N-trimethyl-1-propanaminium
TRIMETHYL[2,3-(DIOLEYLOXY)PROPYL]AMMONIUM CHLORIDE
1,2-DIOLEOYL-3-TRIMETHYLAMMONIUM-PROPANE, CHLORIDE
N-[2,3-Bis(oleoyloxy)propyl]-N,N-dimethylmethanaminium
N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE
N-[1-(2,3-DIOLEOYLOXY) PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE
3-(Trimethylaminio)propane-1,2-diol 1,2-bis[(Z)-9-octadecenoate]
N-[1-(2,3-DIOLEOYLOXY)PROPYL]-N,N,N-TRIMETHYL-AMMONIUM CHLORIDE SALT
N,N,N-TriMethyl-2,3-bis[[(9Z)-1-oxo-9-octadecenyl]oxy]-1-propanaMiniuM | [Molecular Formula]
C42H80ClNO4 | [MDL Number]
MFCD01310872 | [MOL File]
132172-61-3.mol | [Molecular Weight]
698.54 |
| Questions And Answer | Back Directory | [Description]
DOTAP chloride (1,2-Dioleoyl-3-trimethylammonium-propane chloride) is a potent cationic lipid widely used as a liposomal transfection reagent. DOTAP is also a strong activator of the innate immune system in animal cells and could serve as a potential candidate for the study of elicitors of plant immunity. |
| Chemical Properties | Back Directory | [Appearance]
White Foam | [Melting point ]
35-38°C | [storage temp. ]
−20°C
| [solubility ]
Chloroform (Slightly) | [form ]
lyophilized powder
| [color ]
White to Pale Yellow | [Stability:]
Store in Freezer, Hygroscopic | [InChIKey]
KSXTUUUQYQYKCR-LQDDAWAPSA-M | [SMILES]
C(C[N+](C)(C)C)(COC(=O)CCCCCCC/C=C\CCCCCCCC)OC(=O)CCCCCCC/C=C\CCCCCCCC.[Cl-] |
| Hazard Information | Back Directory | [Chemical Properties]
White Foam | [Uses]
Small unilamellar liposomes containing DOTMA interact spontaneously with DNA to form lipid-DNA complexes with 100% entrapment of DNA. Facilitates fusion of the complex with the plasma membrane of tissue culture cells, resulting in both uptake and | [Biochem/physiol Actions]
18:1 TAP (DOTAP) is a cationic lipid structure, used for in vitro and in vivo nucleic acid and protein delivery. The lipid composition and cell type affects the transfection potential of DOTAP(1,2-dioleoyl-3-trimethylammonium-propane). 18:1 TAP (DOTAP) mediates gene knockdown technique in hematopoietic stem cells (HSCs). |
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