| Identification | Back Directory | [Name]
L 683519 | [CAS]
132172-14-6 | [Synonyms]
L 683519
Tacrolimus 13 DMT
Demethyltacrolimus
Desmethyl Tacrolimus
Tacrolimus Impurity 14
Tacrolimus Impurity 23（Desmethyl Tacrolimus）
16,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,15,19-trihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14-methoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,... | [Molecular Formula]
C43H67NO12 | [MOL File]
132172-14-6.mol | [Molecular Weight]
790 |
| Hazard Information | Back Directory | [Uses]
L 683519, one of the impurities of tacrolimus, is an immunosuppressant. L 683519 can inhibit the activity of FK-506 binding protein[1]. | [References]
[1] Chen TS, et al. Microbial transformation of immunosuppressive compounds. II. Specific desmethylation of 13-methoxy group of FK 506 and FR 900520 by an unidentified Actinomycete ATCC 53828 [corrected]. J Antibiot (Tokyo). 1992 Apr;45(4):577-80. DOI:10.7164/antibiotics.45.577 |
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BOC Sciences
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