| Identification | Back Directory | [Name]
methyl 6-(bromomethyl)nicotinate | [CAS]
131803-48-0 | [Synonyms]
methyl 6-(bromomethyl)nicotinate
6-Bromomethyl-nicotinic acid methyl ester
3-Pyridinecarboxylic acid, 6-(broMoMethyl)-
Methyl 2-(bromomethyl)pyridine-5-carboxylate
6-Bromomethylpyridin-3-carboxylic acid methyl ester
6-(bromomethyl)-3-pyridinecarboxylic acid methyl ester
3-Pyridinecarboxylic acid, 6-(bromomethyl)-, methyl ester | [Molecular Formula]
C8H8BrNO2 | [MDL Number]
MFCD10566280 | [MOL File]
131803-48-0.mol | [Molecular Weight]
230.06 |
| Chemical Properties | Back Directory | [Boiling point ]
284.9±30.0℃ (760 Torr) | [density ]
1.533±0.06 g/cm3 (20 ºC 760 Torr) | [Fp ]
126.1±24.6℃ | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
solid | [pka]
1.40±0.22(Predicted) | [color ]
OFF WHITE |
| Hazard Information | Back Directory | [Uses]
methyl 6-(bromomethyl)nicotinate is an organic reagent mainly used in chemical and scientific laboratory research. | [Synthesis]
methyl 6-(bromomethyl)nicotinate is synthesised using methyl 6-methylnicotinate as a raw material by chemical reaction. The specific synthesis steps are as follows:
0.471 g (1.0 equivalent) of N-bromosuccinimide and 64 mg (0.1 equivalent) of benzoyl peroxide are added to a solution of 0.4 g of the product obtained in the preceding Stage 1 in 15 ml of carbon tetrachloride. The solution is brought to reflux for 6 hours, then filtered and evaporated under reduced pressure. The residue is purified by chromatography on silica gel (dichloromethane/ethyl acetate: 95/5) to produce 0.262 g of the expected product. [ Yield: 43percent MS: MH+ 231].
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