| Identification | Back Directory | [Name]
BenzaMide, N-[4-[(4-ethyl-1-piperazinyl)Methyl]-3-(trifluoroMethyl)phenyl]-4-Methyl-3-[(6-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)oxy]- | [CAS]
1315330-11-0 | [Synonyms]
CS-1492
AK122840
HY-77251
AKOS016012030
SureCN14689441
TAK1/MAP4K2 INHIBITOR 1
B-Raf inhibitor (BenzaMide)
TAK1/MAP4K2 inhibitor 1,TAK-1/MAP4K2 inhibitor 1
1315330-11-0; SURECN14689441; AKOS016012030; B-RAF INHIBITOR;1315330-11-0; CS-1099; AK122840; HY-77251
N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[(6-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]benzamide
BenzaMide, N-[4-[(4-ethyl-1-piperazinyl)Methyl]-3-(trifluoroMethyl)phenyl]-4-Methyl-3-[(6-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)oxy]- | [Molecular Formula]
C29H31F3N6O2 | [MDL Number]
MFCD22572824 | [MOL File]
1315330-11-0.mol | [Molecular Weight]
552.59 |
| Chemical Properties | Back Directory | [density ]
1.319±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 50 mg/mL (90.48 mM; Need ultrasonic) | [form ]
Powder | [pka]
12.43±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TAK1/MAP4K2 inhibitor 1 is a potent dual TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) inhibitor, with IC50s of 41.1 nM and 18.2 nM, respectively. | [in vivo]
TAK1/MAP4K2 inhibitor 1 has moderate terminal elimination half-life (t1/2=2.94 h for mice (1 mg/kg, iv))[1]. | [IC 50]
TAK1: 41.1 nM (IC50); MAP4K2: 18.2 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Tan L, et al. Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J Med Chem. 2015 Jan 8;58(1):183-96. DOI:10.1021/jm500480k |
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BOC Sciences
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