| Identification | Back Directory | [Name]
(S)-2-(4-(1,8-Naphthyridin-2-yl)phenyl)-N-(1-(4’-fluoro-3’-(trifluoromethyl)-[1,1’-biphenyl]-4-yl)ethyl)acetamide | [CAS]
1314796-00-3 | [Synonyms]
hGPR91 antagonist 1
Inhibitor,inhibit,hGPR91 antagonist 1,hGPR-91 antagonist 1
(S)-2-(4-(1,8-Naphthyridin-2-yl)phenyl)-N-(1-(4’-fluoro-3’-(trifluoromethyl)-[1,1’-biphenyl]-4-yl)ethyl)acetamide | [Molecular Formula]
C31H23F4N3O | [MDL Number]
MFCD31811561 | [MOL File]
1314796-00-3.mol | [Molecular Weight]
529.53 |
| Chemical Properties | Back Directory | [Melting point ]
198-200 °C | [Boiling point ]
708.6±60.0 °C(Predicted) | [density ]
1.286±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
14.74±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
HGPR91 antagonist 1 is a potent and selective small molecule hGPR91 antagonist with an IC50 of 7 μM[1].
IC50: 7 μM (HGPR91)[1] HGPR91 antagonist 1 leads to 59, 76% inhibition of δMAP at 2, 4 hours and has shown rat plasma protein binding 99%. HGPR91 antagonist 1 has engaged the target under the in vivo condition. HGPR91 antagonist 1 has clearance (CL) of 0.2 nmol/min/mg of RLM[1]. Animal Model: Wistar rats[1] | [storage]
Store at -20°C | [References]
[1]. Bhuniya D, et al. Discovery of a potent and selective small molecule hGPR91 antagonist. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3596-602. |
|
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
|