| Identification | Back Directory | [Name]
Mes-PEG2-acid t-butyl ester | [CAS]
1312309-62-8 | [Synonyms]
Ms-PEG2-C2-Boc
CAS_1312309-62-8
Ms-PEG2-t-butyl ester
Mes-PEG2-acid t-butyl ester
4,7,10-Trioxa-11-thiadodecanoic acid, 1,1-dimethylethyl ester, 11,11-dioxide | [Molecular Formula]
C12H24O7S | [MDL Number]
MFCD20926372 | [MOL File]
1312309-62-8.mol | [Molecular Weight]
312.38 |
| Chemical Properties | Back Directory | [Boiling point ]
429.2±30.0 °C(Predicted) | [density ]
1.155±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Ms-PEG2-t-butyl ester is a PEG linker containing a mesyl group and a t-butyl protecting group. The mesyl group is a good leaving group for nucleophilic substitution reactions. The t-butyl is an acid labile protecting group. Upon removal, the carboxylic acid can react with primary amines. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. | [Uses]
Ms-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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Wuhan Topule
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http://www.topule.com/ |
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