| Identification | Back Directory | [Name]
1,2-Benzisothiazol-3(2H)-one, 5-fluoro-2-phenyl- | [CAS]
1306638-12-9 | [Synonyms]
ML089
1,2-Benzisothiazol-3(2H)-one, 5-fluoro-2-phenyl- | [Molecular Formula]
C13H8FNOS | [MOL File]
1306638-12-9.mol | [Molecular Weight]
245.27 |
| Chemical Properties | Back Directory | [Boiling point ]
400.2±47.0 °C(Predicted) | [density ]
1.409±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
-3.19±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Definition]
ChEBI: 5-fluoro-2-phenyl-1,2-benzothiazol-3-one is a member of benzothiazoles. | [Biological Activity]
ML089 is a potent, selective, and orally available phosphomannose isomerase (PMI) inhibitor with an IC50 of 1.3 µM. ML089 can be used for the research of congenital disorder of glycosylation Ia[1][2]. | [storage]
Store at -20°C | [References]
[1]. Russell Dahl, et al. Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia. J Med Chem. 2011 May 26;54(10):3661-8. |
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