| Identification | Back Directory | [Name]
Eplivanserin | [CAS]
130579-75-8 | [Synonyms]
EPLIVANSERIN
VAIOZOCLKVMIMN-PRJWTAEASA-N
(Z,E)-1-(2-Fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-one O-[2-(dimethylamino)ethyl]oxime | [Molecular Formula]
C19H21FN2O2 | [MDL Number]
MFCD00893359 | [MOL File]
130579-75-8.mol | [Molecular Weight]
328.38 |
| Chemical Properties | Back Directory | [Boiling point ]
453.4±55.0 °C(Predicted) | [density ]
1.08 | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
9.60±0.15(Predicted) |
| Hazard Information | Back Directory | [Uses]
Eplivanserin is used in the treatment of dystonia. | [in vivo]
Eplivanserin hemifumarate (SR 46349B) inhibits 5-HT2 receptor binding of [3H]ketanserin with an ED50 of 0.087 mg/kg after i.p. injection, and 0.097 mg/kg after p.o administration in mice[1].
SR 46349B (0.25-1 mg/kg; i.p.) blocks Cocaine-evoked hyperactivity following repeated Cocaine treatment in rats[2]. | [IC 50]
5-HT2A Receptor: 5.8 nM (IC50, in rat cortical membrane); 5-HT2A Receptor: 1.14 nM (Ki); 5-HT2C Receptor: 120 nM (IC50) |
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LGM Pharma
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1-(800)-881-8210 |
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ChemCell Biomedicine Co.,Ltd.
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