| Identification | Back Directory | [Name]
(R,S)-Methyl-2-(2-chlorophenyl)-2-(4,5,6,7-tetrahydrothino[3.2-c]pyridin-5-yl)acetatehydrochloride | [CAS]
130209-90-4 | [Synonyms]
(+/-)-Clopidogrelhydrochloride
(+/-)-Clopidogrel hydrochloride
DISCONTINUED
(R,S)-Methyl-2-(2-chlorophenyl)-2-(4,5,6,7-tetrahydrothino[3.2-c]pyridin-5-yl)acetateHCl
METHYL 2-(2-CHLOROPHENYL)-2-(4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDIN-5-YL)ACETATE HYDROCHLORIDE
(R,S)-Methyl-2-(2-chlorophenyl)-2-(4,5,6,7-tetrahydrothino[3.2-c]pyridin-5-yl)acetatehydrochloride | [Molecular Formula]
C16H17Cl2NO2S | [MOL File]
130209-90-4.mol | [Molecular Weight]
358.28 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.33 mg/ml; Ethanol: 5 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM).1,2 Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active metabolite via CYP2C19 in the liver enables its anti-aggregating activity.3 Marketed under the name Plavix?, clopidogrel in combination with aspirin has been shown to be beneficial in the prevention of vascular ischemic events for patients without deficiencies in CYP2C19-related metabolism.4 | [storage]
+4°C (desiccate) | [References]
1. Savi, P., Labouret, C., Delesque, N., et al. P2Y12, a new platelet ADP receptor, target of clopidogrel Biochem. Bioph. Res. Commun. 283(2),379-383(2001).
2. von Kügelgen, I. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes Pharmacol. Ther. 110(3),415-432(2006).
3. Quinn, M.J., and Fitzgerald, D.J. Ticlopidine and clopidogrel Circulation 100(15),1667-1672(1999).
4. Angiolillo, D.J., Fernandez-Ortiz, A., Bernardo, E., et al. Variability in individual responsiveness to clopidogrel: Clinical implications, management, and future perspectives J. Am. Coll. Cardiol. 49(14),1505-1516(2007). |
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Energy Chemical
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