| Identification | Back Directory | [Name]
E1R | [CAS]
1301211-78-8 | [Synonyms]
E1R
1-Pyrrolidineacetamide, 2-methyl-5-oxo-3-phenyl-, (2S,3R)- | [Molecular Formula]
C13H16N2O2 | [MDL Number]
MFCD32067912 | [MOL File]
1301211-78-8.mol | [Molecular Weight]
232.28 |
| Chemical Properties | Back Directory | [Boiling point ]
480.0±45.0 °C(Predicted) | [density ]
1.168±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 60 mg/mL (258.31 mM) | [form ]
Solid | [pka]
15.67±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
E1R is a positive allosteric modulator of the sigma-1 receptor (Sig1R PAM) with cognitive enhancing effects. | [in vitro]
The only target for E1R (inhibition or enhancement of radioligand binding exceeding 20%) is the sigma receptor. 10 μM E1R does not displace the radioligand, but instead increases the specific binding of a non-selective radioligand ([ 3 H]1,3-di(2-tolyl)guanidine) for the sigma receptor by 38% in Jurkat cells. | [in vivo]
E1R demonstrates efficacy against scopolamine-induced cholinergic dysfunction in mice. Treatment with E1R (0.1-10 mg/kg; administered ip 60 min before the training session) significantly improves cognitive function in a dose-related manner in mice . | Animal Model: | Male ICR and Balb/c mice weighed 23-25 g | | Dosage: | 0.1, 1 and 10 mg/kg | | Administration: | Administered ip 60 min before the training session | | Result: | Treatment at doses of 1 and 10 mg/kg increased retention latency by 194 and 211%, respectively, compared with the control group. | | [storage]
Store at -20°C |
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MedChemExpress
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www.medchemexpress.com |
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