| Identification | Back Directory | [Name]
Verteporfin | [CAS]
129497-78-5 | [Synonyms]
Visudyne
CL 318952
Verteporfin
Verteprofin
Verteporphin
Verteporfin(DB00460)
VERTEPORFIN (200 MG)
trans-3,4-Dicarboxy-4,4a-dihydro-4a,8,14,19-tetramethyl-18-vinyl-23H,25H-benzo(b)porphine-9,13-dipropionic acid 3,4,9-trimethyl ester
(4R,4aS)-rel-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-Benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
24H,26H-Benzo[b]porphine-9,13-dipropanoic acid, 18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-, monomethyl ester, (4R,4aS)-rel-
3-[(23S,24R)-14-Ethenyl-5-(3-methoxy-3-oxopropyl)-22,23-bis(methoxycarbonyl)-4,10,15,24-tetramethyl-25,26,27,28-tetraazahexacyclo[16.6.1.13,6.18,11.113,16.019,24]octacosa-1,3,5,7,9,11(27),12,14,16,18(25),19,21-dodecaen-9-yl]propanoic acid | [Molecular Formula]
2C41H42N4O8 | [MDL Number]
MFCD11982858 | [MOL File]
129497-78-5.mol | [Molecular Weight]
1437.61 |
| Chemical Properties | Back Directory | [storage temp. ]
?20°C | [solubility ]
DMSO: soluble2mg/mL, clear (warmed) | [form ]
powder | [color ]
Black | [Stability:]
Stable for 2 years from date of purchsae as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | [InChIKey]
YHNBVDZVUQFVLS-RDSGBMLISA-N |
| Hazard Information | Back Directory | [Uses]
Treatment of age-related macular degeneration | [Description]
Verteporfin was introduced in Switzerland as a second-generation photosensitizer for
photodynamic therapy of wet age-related macular degeneration in patients with subfoveal
choroidal neovascularisation. It is constituted of a mixture of two regioisomers resulting
from nonselective monohydrolysis of the methyl tetraester. Upon irradiation with a lowenergy
nonheat-generating laser light of 689nm wavelength, both regioisomeric
benzoporphyrins are responsible for the local generation of singlet oxygen leading to free
radical damage of neovascular endothelial cells in subfoveal lesions of patients with agerelated
macular degeneration. The lipophilic drug is injected i.v. as a liposomal formulation
in order to favor its uptake by plasma lipoproteins and distribution to cells with a high
expression of low density lipoprotein receptors such as tumor and neovascular endothelial
cells. Verteporfin is also being developed for the treatment of other eye diseases, nonmelanoma
skin cancer and psoriasis. | [Originator]
QLT Inc. (Canada) | [Brand name]
Visudyne (QLT). | [Biochem/physiol Actions]
Verteporfin is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as macular degeneration. Verteporfin accumulates in abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 nm in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels. Verteporfin localizes predominantly in mitochondria. | [storage]
Store at -20°C | [References]
References/Citations: |
| Questions And Answer | Back Directory | [Photosensitizer]
Verteporfin (trade name Visudyne) belongs to a second generation of porphyrin-based photosensitizer that can be activated by light (wavelength 689nm). It can be used for photodynamic therapy for macular degeneration. Drugs can selectively penetrate into the abnormal blood vessels, generate reactive oxygen species and occlude the abnormal blood vessels with the help of non-thermal laser irradiation, further terminating blood vessel leakage, and saving vision.
Upon being activated by the light, Visudyne forms a cytotoxic product in an aerobic environment. During this process, the porphyrin transfers the absorbed energy to oxygen and forms single-oxygen with a high activity and a short maintenance time. The single-oxygen destroys the biological structure within its range of diffusion. This process leads to localized vascular atresia and cell destruction, further leading to cell death in a particular environment.
In plasma, verteporfin is mainly carried by low density lipoprotein (LDL). The application of Visudyne for photodynamic therapy (PDT) has selectivity. On the one hand, it depends on the choice of light irradiation site. On the other hand, the expression of LDL receptors is enhanced in rapidly proliferating cells, including choroidal neovascular endothelial cells, so that rapid proliferative cells can selectively and rapidly ingest and accumulate verteporfin. Choroidal neovascularization is more rapid and selective than retinal pigment epithelium in absorbing the Visudyne, whereas in other ocular structures, the drug content is small. Therefore, the drug can selectively destroy choroidal neovascularization. It can be used for the treatment of continuous deterioration or loss of vision caused by wet age-related macular degeneration, pathological myopia and ocular histoplasmosis related to the choroidal neovascularization
The above information is edited Andy from ChemicalBook. | [Administration and Dosage]
Verteporfin is suitable for the treatment of patients of age-related macular degeneration, pathologic myopia or suspected ocular histoplasmosis with a typical predominantly central choroidal neovascularization. There is no sufficient evidence to support its efficacy on the treatment of patients with occult central choroidal neovascularization.
Intravenous administration, the drug treatment process contains two steps: ① intravenous administration: Formulate 2 mg/mL injection with sterile injection of water at a body surface area of 6 mg/m2. Diluted to 30 mL with 5% GS and inject for 10 minutes at the rate of 3mL/min. The diluent should be avoided of light within 4 hours. ② non-thermal diode laser activation: within the 15 minutes after the start of injection, apply a laser of constant energy at wavelength of 689 ± 3nm for irradiation towards patients. During the treatment of choroidal neovascularization, the recommended laser dose at the local focus should be 50 J/ cm2 with laser intensity of 600mW/cm2. The irradiation process should be completed within 83 seconds. | [Adverse reactions]
Common adverse effects of Visudyne include visual impairment. Local infusion and rash may occur during local injection. It can be occurred of cataract, diplopia, tears, conjunctivitis, dry eyes, eye itching, severe visual loss and conjunctiva, retinal and vitreous hemorrhage, high blood pressure, atrial fibrillation, peripheral vascular disorders, varicose veins, hypoesthesia, sleep disorders, headache, dizziness, weakness, fever, creatinine, cough, pharyngitis, pneumonia, influenza-like syndrome, back pain, abnormal liver function test indicators, prostate disorders, proteinuria, nausea, constipation, gastrointestinal cancer, eczema, anemia, reduction or increases in leukocyte count, hearing impairment and so on. | [Precautions]
Visudyne should be disabled in patients who are highly allergic to it and its derivatives, and patients who received other photosensitizers within 3 months or with porphyria. Patients of serious or moderately serious liver dysfunction should be cautious upon receiving vitamin treatment. Vitamin and other drugs should not be dissolved in the same solution. Avoid direct exposure to drugs. If a patient has a severe vision loss (vision loss or more than 4 lines) within 1 week after treatment, the patients should discontinue the treatment until the vision returns to the initial state. Care should be taken before weighing the pros and cons of treatment. Patients of liver dysfunction and photodynamic therapy discomfort should take with caution; patients, within 6 days after treatment, should avoid exposure of the skin and eyes to light; avoid excessive and prolonged treatment. Do not use in a brightly lit environment. Avoid the use of visudyne salt solution. If liquid spills, wipe it with a damp cloth. Do not let it touch the eye or skin. Verteporfin leakage may cause severe pain, inflammatory reactions, and discoloration at the injection site. Analgesics can be simultaneously given to relieve pain during the injection. If you find verteporfin leakage, immediately stop the injection, and give cold pressure. The affected area should be carefully protected against direct light exposure until swelling and skin color return to normal. Vitamins should be used with care for patients with general anesthesia.
Patients treated with Visudyne were in a light-sensitive state within 48 hours of injection. Within 48 hours of treatment, the skin and eyes mustn’t be exposed directly to daylight or bright artificial light. If you have to be exposed to the outdoors during the day within 48 hours of treatment, you should wear a suitable jacket and wear sunglasses for protection. |
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