| Identification | Back Directory | [Name]
(±)16-HETE | [CAS]
128914-46-5 | [Synonyms]
(±)16-HETE
JEKNPVYFNMZRJG-UFINWASNSA-N
16-hydroxy-5(Z),8(Z),11(Z),14(Z)-eicosatetraenoic acid
5,8,11,14-Eicosatetraenoic acid, 16-hydroxy-, (5Z,8Z,11Z,14Z)- | [Molecular Formula]
C20H32O3 | [MOL File]
128914-46-5.mol | [Molecular Weight]
320.47 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml |
| Hazard Information | Back Directory | [Description]
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 μM the (S)-enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R)-isomer has negligible effects on ATPase activity. | [Definition]
ChEBI: A HETE that consists of arachidonic acid bearing an additional hydroxy substituent at position 16. | [storage]
Store at -20°C |
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