| Identification | Back Directory | [Name]
CINALUKAST | [CAS]
128312-51-6 | [Synonyms]
Ro 24-591
CINALUKAST
RO 24-5913
C·Nalukast
2,2-Diethyl-N-[3-[(E)-2-(4-cyclobutyl-2-thiazolyl)ethenyl]phenyl]succinamidic acid
(E)-4-[[3-(2-(4-CYCLOBUTYL-2-THIAZOLYL)ETHENYL)PHENYL]AMINO]-2,2-DIETHYL-4-OXOBUTANOIC ACID
4-[[3-[(1E)-2-(4-CYCLOBUTYL-2-THIAZOLYL)ETHENYL]PHENYL]AMINO]-2,2-DIETHYL-4-OXOBUTANOIC ACID
Butanoic acid, 4-[[3-[(1E)-2-(4-cyclobutyl-2-thiazolyl)ethenyl]phenyl]aMino]-2,2-diethyl-4-oxo-
Ro 24-5913, (E)-4-[[3-(2-(4-Cyclobutyl-2-thiazolyl)ethenyl)phenyl]amino]-2,2-diethyl-4-oxobutanoic acid | [Molecular Formula]
C23H28N2O3S | [MDL Number]
MFCD00864778 | [MOL File]
128312-51-6.mol | [Molecular Weight]
412.55 |
| Hazard Information | Back Directory | [Uses]
A novel leukotriene D4 antagonist | [Uses]
A novel leukotriene D4 antagonist. | [Definition]
ChEBI: 2,2-Diethylsuccinanilic acid substituted at a meta- position by an (E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl group. It selectively antagonizes leukotriene D4 at the cysteinyl leukotriene receptor, in th
human airway, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus. It is used in the treatment of asthma. | [Biological Activity]
Potent, selective CysLT 1 (LTD 4 ) leukotriene receptor antagonist (IC 50 = 6.4 nM). Inhibits LTD 4 -induced bronchoconstriction in guinea pigs when administered intravenously, orally or by aerosol. | [storage]
Desiccate at -20°C |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Carbosynth
|
| Tel: |
+86 512 6260 5585 |
| Website: |
www.carbosynth.com |
|