| Identification | Back Directory | [Name]
DODAP | [CAS]
127512-29-2 | [Synonyms]
DODAP
18:1 DAP
1,2-DIOLEOYL-3-DIMETHYLAMMONIUM-PROPANE
1,2-DIOLEOYLOXY-3-(DIMETHYLAMINO)PROPANE
9-Octadecenoic acid(9Z)-1,1'-[1-[(dimethylamino)methyl]-1,2-ethanediyl] ester | [Molecular Formula]
C41H77NO4 | [MDL Number]
MFCD01321074 | [MOL File]
127512-29-2.mol | [Molecular Weight]
648.05 |
| Chemical Properties | Back Directory | [Appearance]
Light Yellow Oil | [Boiling point ]
670.1±55.0 °C(Predicted) | [density ]
0.916±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer, Under Inert Atmosphere | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
Oil | [pka]
8.02±0.28(Predicted) | [color ]
Colourless to Light Yellow | [Stability:]
Light Sensitive; Hydroscopic; Store at -15 to -25°C | [InChIKey]
NYDLOCKCVISJKK-WRBBJXAJSA-N | [SMILES]
C(OC(=O)CCCCCCC/C=C\CCCCCCCC)(CN(C)C)COC(=O)CCCCCCC/C=C\CCCCCCCC |
| Hazard Information | Back Directory | [Chemical Properties]
Light Yellow Oil | [Uses]
Cationic amphiphiles are being studied for their potential role in preparing liposomes for interaction with artificial and biological membranes and cellular transfection techniques. Cationic species with ester linkages to the hydrophobic portion are more easily degraded by recipient cells and more efficiently metabolized. | [Description]
DODAP (18:1) is an ionizable cationic lipid with lower cytotoxicity and high transfection efficiency. DODAP is neutral at physiological pH, but acquires a positive charge inside the endosome due to the protonation of free amines when pH is lower than its pKa (<7). |
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