| Identification | Back Directory | [Name]
N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE | [CAS]
127408-31-5 | [Synonyms]
Y-26763
N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE
Acetamide, N-[(3S,4R)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxy- | [Molecular Formula]
C14H16N2O4 | [MDL Number]
MFCD00888284 | [MOL File]
127408-31-5.mol | [Molecular Weight]
276.29 |
| Chemical Properties | Back Directory | [Boiling point ]
455.4±55.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
Soluble to 100 mM in 1eq. NaOH | [form ]
Powder | [pka]
8.69±0.60(Predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Uses]
Y-26763, is a Kir6 (KATP) channel opener. It also inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. In vivo, it has shown to have hypotension activity in rats and cardioprotective properties in dogs. | [Definition]
ChEBI: N-[(3S,4R)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl]-N-hydroxyacetamide is a 1-benzopyran. | [Biological Activity]
K ATP channel opener and active metabolite of Y-27152 (N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide ). In vitro, causes relaxation of contracted rat aortic rings (IC 50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic b-cells. In vivo, produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration. | [storage]
Store at RT |
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