| Identification | Back Directory | [Name]
CGP 42112 | [CAS]
127060-75-7 | [Synonyms]
CGP 42112
CGP-42112A
CGP42112A, CGP42112
CGP-42112
(CGP42112
ANGIOTENSIN II ANTAGONIST
ANGIOTENSIN II RECEPTOR LIGAND
NIC-TYR-LYS(Z-ARG)-HIS-PRO-ILE
CGP-42112A >=95%, synthetic, solid
NICOTINOYL-TYR-LYS(CBZ-ARG)-HIS-PRO-ILE
NICOTINOYL-TYR-LYS(Z-ARG)-HIS-PRO-ILE-OH
nα-nicotinoyl-tyr-(nα-cbz-arg)-lys-his-pro-ile
CGP42112;CGP 42112;CGP-42112A;CGP42112A;CGP 42112A
N-NICOTINOYL-TYR-N-EPSILON(NA-CBZ-ARG)-L YS-HIS-PRO
CGP-42112A >98% SYNTHETIC (POTENTANGIOTE NSIN II TYPE A
N-ALPHA-NICOTINOYL-TYR-LYS(N-ALPHA-CBZ-ARG)-HIS-PRO-ILE
CGP 42112;NΑ-NICOTINOYL-TYR-(NΑ-CBZ-ARG)-LYS-HIS-PRO-ILE
N-ALPHA-NICOTINOYL-TYR-(N-ALPHA-CBZ-ARG)-LYS-HIS-PRO-ILE-OH
Angiotensin II Receptor Ligand Nicotinoyl-Tyr-Lys(Z-Arg)-His-Pro-Ile-OH
N6-[[(Phenylmethoxy)carbonyl]-L-Arg-]-N2-[[(pyridin-3-yl)carbonyl]-L-Tyr-]-L-Lys-L-His-L-Pro-L-Ile-OH
[N-ALPHA-(NICOTINOYL-L-TYROSYL)-N-EPSILON-(N-ALPHA-Z-L-ARGINYL)-L-LYSYL]-L HISTIDYL-L-PROLYL-L-ISOLEUCINE
L-Isoleucine, N-(3-pyridinylcarbonyl)-L-tyrosyl-N6-[N2-[(phenylmethoxy)carbonyl]-L-arginyl]-L-lysyl-L-histidyl-L-prolyl- | [Molecular Formula]
C52H69N13O11 | [MDL Number]
MFCD00133611 | [MOL File]
127060-75-7.mol | [Molecular Weight]
1052.18 |
| Chemical Properties | Back Directory | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO:350.0(Max Conc. mg/mL);332.64(Max Conc. mM) | [form ]
solid
| [pka]
3.72±0.22(Predicted) | [color ]
white
| [biological source]
synthetic | [Water Solubility ]
Soluble to 1 mg/ml in water | [BRN ]
8184948 |
| Hazard Information | Back Directory | [Uses]
CGP-42112A has been used:
- in the isolation of RNA from fibroblast-like synoviocytes from rheumatoid arthritis patients (RA-FLS)
- to study its effects on the ERK2 phosphorylation in the cardiomyoblast cell line
- as a stimulator of angiotensin II type 2 (AT2) receptor to study its effects on human regional hemodynamic responses mediated by AT2 receptors
| [Definition]
ChEBI:CGP-42112A is a hexapeptide consisting of L-tyrosine, L-lysine, L-histidine, L-proline and L-isoleucine amino acid residues coupled in sequence and in which the amino group of the L-tyrosyl residue is substituted by a (pyridin-3-ylcarbonyl)nitrilo group and in which the L-lysyl side chain amino group is substituted by a {N(2)-[(benzyloxy)carbonyl]-L-arginyl}nitrilo group. It is a potent angiotensin II receptor type 2 (AT2 receptor) agonist. It has a role as an angiotensin receptor agonist, a vasodilator agent, an antineoplastic agent, an anti-inflammatory agent and a neuroprotective agent. It is an oligopeptide, a benzyl ester and a pyridinecarboxamide. | [Biochem/physiol Actions]
Potent AT2 angiotensin II receptor agonist. | [in vivo]
Intravenous infusions of CGP-42112 (0.1 and 1 mg kg-1 min-1) and PD 123319 (0.36 and 1 mg kg-1 min-1) shifted the upper limit of CBF autoregulation toward higher blood pressures without affecting baseline CBF[3]. | [IC 50]
AT2 Receptor; AT1 Receptor | [storage]
Desiccate at -20°C |
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