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ChemicalBook--->CAS DataBase List--->1269826-44-9

1269826-44-9

1269826-44-9 Structure

1269826-44-9 Structure
IdentificationBack Directory
[Name]

3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)-
[CAS]

1269826-44-9
[Synonyms]

OSBPL7-IN-1
3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)-
[Molecular Formula]

C20H19Cl2F3N2O3
[MOL File]

1269826-44-9.mol
[Molecular Weight]

463.28
Chemical PropertiesBack Directory
[Boiling point ]

540.9±50.0 °C(Predicted)
[density ]

1.46±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[form ]

Solid
[pka]

5.98±0.40(Predicted)
[color ]

White to off-white
Spectrum DetailBack Directory
[Spectrum Detail]

3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)-(1269826-44-9)1HNMR
Hazard InformationBack Directory
[Biological Activity]

OSBPL7-IN-1 is an orally active oxysterol binding protein like 7 (OSBPL7) inhibitor. OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1]. OSBPL7-IN-1 (compound G or Cpd G; 1-10 μM) increase plasma membrane ATP-binding cassette transporter (ABCA1) in cultured human podocytes, and significantly increase ABCA1-dependent cholesterol efflux[1]. OSBPL7-IN-1 (100 mg/kg; oral gavage; daily; for 28 days) treatment normalizes proteinuria and prevents renal function decline in mouse models of proteinuric kidney disease[1].
[References]

[1]. Matthew B Wright, et al. Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease. Nat Commun. 2021 Aug 2;12(1):4662.
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