| Identification | Back Directory | [Name]
Abacavir-d4 | [CAS]
1260619-56-4 | [Synonyms]
ABC-d4
Ziagen-d4
1592U89-d4
Abacavir-d4
Abacavir-d4
(1S,4R)-4-[2-Amino-6-[(cyclopropyl-d4)amino]-9H-purin-9-yl]-2-cycpentene-1-methanol
(1S,4R)-4-[2-AMino-6-(cyclopropylaMino-d4)-9H-purin-9-yl]-2-cyclopentene-1-Methanol
(1S-cis)-4-[2-AMino-6-(cyclopropylaMino-d4)-9H-purin-9-yl]-2-cyclopentene-
1-Methanol | [Molecular Formula]
C14H18N6O | [MDL Number]
MFCD11977959 | [MOL File]
1260619-56-4.mol | [Molecular Weight]
286.332 |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
222-225°C | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Off-White to Light Beige | [Stability:]
Very Hygroscopic |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
A labelled nucleoside reverse transcriptase inhibitor (NRTI) | [Description]
Abacavir-d4 is intended for use as an internal standard for the quantification of abacavir by GC- or LC-MS. Abacavir is a nucleoside analog and an inhibitor of HIV-1 reverse transcriptase (Ki = 2.1 μM for the wild-type enzyme). It inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to 3''-azido-3''-deoxythymidine (zidovudine; ) or 2'',3''-dideoxyinosine (didanosine; ), in HeLa cells stably expressing CD4 (IC50s = 5.8-21 μM). Abacavir inhibits replication of eight HIV-1 clinical isolates in phytohemagglutinin-stimulated isolated human peripheral blood lymphocytes with a mean IC50 value of 0.26 μM. It inhibits hepatitis B virus (HBV) DNA synthesis in HepG2 cells (IC50 = 7 μM) and is also active against human cytomegalovirus (CMV) strain AD169 and the Petaluma strain of feline immunodeficiency virus (FIV) in plaque reduction assays (IC50s = 32 and 0.4 μM, respectively). Formulations containing abacavir have been used in the treatment of HIV infection. |
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