| Identification | Back Directory | [Name]
N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester | [CAS]
1256490-31-9 | [Synonyms]
EOS-61207
2. N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine
isopropyl((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)-L-alaninate
N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-methyl...
N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-methylethyl este
N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester
L-Alanine, N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester
(S)-Isopropyl 2-(((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C18H21N2O7P | [MDL Number]
MFCD28978357 | [MOL File]
1256490-31-9.mol | [Molecular Weight]
408.34 |
| Chemical Properties | Back Directory | [Melting point ]
62-66℃ | [Boiling point ]
514.3±60.0 °C(Predicted) | [density ]
1.302 | [storage temp. ]
2-8°C | [solubility ]
Dichloromethane, Ethyl Acetate, Methanol | [form ]
Solid | [pka]
-5.78±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. |
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