| Identification | Back Directory | [Name]
6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole | [CAS]
1254036-71-9 | [Synonyms]
CS-2340
Nemiralisib
GSK2269557 (free base)
gsk2269557(Nemiralisib)
Nemiralisib(GSK2269557)
GSK 2269557;GSK-2269557
PI3Kδ inhibitor GS2269557
Nemiralisib (GSK2269557 free base)
6-(1H-indol-4-yl)-4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazole
1H-Indazole, 6-(1H-indol-4-yl)-4-[5-[[4-(1-methylethyl)-1-piperazinyl]methyl]-2-oxazolyl]- | [Molecular Formula]
C26H28N6O | [MDL Number]
MFCD28128611 | [MOL File]
1254036-71-9.mol | [Molecular Weight]
440.54 |
| Chemical Properties | Back Directory | [Boiling point ]
706.2±70.0 °C(Predicted) | [density ]
1.281±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 33.33 mg/mL (75.66 mM) | [form ]
Solid | [pka]
12.90±0.40(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Biological Activity]
Nemiralisib, also known as GSK-2269557, is a potent and selective PI3Kδ inhibitor (pKi=9.9). | [in vivo]
Nemiralisib has relatively low oral bioavailability (F=2%), in vivo clearance is 28 mL/min/kg, but high volume distribution, 6.3 L/kg. 0.3-1 μMGSK-2269557 induction concentration Dependent QT interval and Tpe prolongation, 1 μM GSK-2269557 resulted in prolongation of the ORS wave, during which no torsades de pointes arrhythmia was observed. | [target]
| Target | Value | PI3Kδ
(Cell-free assay) | 9.9(pKi) |
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Musechem
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DC Chemicals
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Cckinase, Inc.
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+1 (732)236-3202 |
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www.cckinase.com |
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