| Chemical Properties | Back Directory | [Melting point ]
171-172 °C | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 41.67 mg/mL (67.48 mM) | [form ]
Solid | [pka]
11.17±0.20(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Biological Activity]
TM38837 is a peripherally selective cannabinoid receptor type 1 (CB1) receptor antagonist. It has limited brain penetration to minimize or prevent CNS adverse effects and retain potential anti-obesity effects. Also it can reduces the propensity for psychotic side effects. | [in vivo]
TM38837 (10-100 mg/kg; po) induces a significant increase in freezing behavior at 100 mg/kg. | Animal Model: | < td class="col2"> 7-8 weeks old male C57BL/6 N mice (B6N) | Dosage: | 10, 30, or 100 mg/kg | | Administration: | po < /td> | | Result: | High dose (100 mg/kg) induced a significant increase in freezing behavior. < /td> | | [target]
| [storage]
Store at -20°C |
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