| Identification | Back Directory | [Name]
GB 83 | [CAS]
1252806-86-2 | [Synonyms]
GB 83
GB-83
(GB83)
5-Isoxazolecarboxamide, N-[(1S)-1-(cyclohexylmethyl)-2-[[(1S,2S)-1-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]-2-methylbutyl]amino]-2-oxoethyl]- | [Molecular Formula]
C32H44N4O4 | [MDL Number]
MFCD20926417 | [MOL File]
1252806-86-2.mol | [Molecular Weight]
548.72 |
| Chemical Properties | Back Directory | [Boiling point ]
807.6±65.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
12.12±0.46(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Biological Activity]
GB83 is a serum stablepotent and selective antagonist of human protease activated receptor 2 (PAR2)(IC50 = 2 μM) th at reversibly inhibit PAR2 activation by both proteases and PAR2 agonists. GB83 prevented upregulation of PARsICAM-1LOX-1IL-8and activation of MAP kinases by coagulation factor X (FXa) in atrial tissue slices |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
|